A Study of Clinical Profile of Chronic Liver Disease with Special Reference to Renal Function Tests

Abstract

^{Background: Chronic liver disease accounts for major morbidity and mortality worldwide. It can affect renal function and lead to complications such as hepatorenal syndrome.}

^{Aim : To study clinical profile of chronic liver disease with special reference to renal function tests.}

^{Objectives : 1. To study clinical profile of chronic liver disease. 2. To assess renal function in chronic liver disease. 3. To evaluate the association of alteration of renal function with gradation of liver disease (assessed by Child Pugh score).}

^{Materials and Methods : This hospital based longitudinal study was conducted at a tertiary care centre under Department of Medicine from 1st Oct 2022 to 31st June 2024. A total of 150 patients with chronic liver disease were enrolled and their demographic, clinical and laboratory data was collected. RFT was performed using blood urea and serum creatinine. Severity of CLD was assessed using Child Pugh score. Data was analysed by R Software version 4.3.2.}

^{Results : The result shows that - 1. Mean age of the study population was 49.89 years and 80.67% were male. 2. Most common cause of CLD  was alcoholic liver disease (72.67%) followed by Hepatitis B (19.33%) and Hepatitis C (3.33%). 3. The distribution of serum urea and serum creatinine according to severity of liver disease as per Child Pugh classification were statistically significant.}

^{Conclusion : CLD significantly impacts renal function. Prognostic markers like Child Pugh score along with biochemical parameters help identify patients at risk. Present study  has found significant association between severity of liver dysfunction and certain parameters of renal dysfunction.}