Study of effect of acute coronary syndrome and stroke on lipid profile at tertiary care centre

Abstract

Cardiovascular disease (CVD), including acute coronary syndrome (ACS) and stroke, is a leading global cause of mortality. Dyslipidemia, a key modifiable risk factor, significantly influences the pathophysiology of both conditions, particularly through its role in atherosclerosis. This study examines the effect of ACS and stroke on lipid profiles during the acute phase, with lipid parameters monitored over a four-week period post-hospitalization. A total of 50 patients aged 18–75 years were included, with 33 males and 17 females. Baseline lipid profiles—total cholesterol, LDL-C, HDL-C, and triglycerides—were assessed at intervals of 72 hours, one week, and four weeks post-event. Results revealed significant reductions in total cholesterol, HDL-C, and LDL-C levels at 72 hours and one week, followed by partial recovery at four weeks. Triglyceride levels increased significantly during the first week, remaining elevated throughout the study. These findings suggest that lipid metabolism undergoes transient disruption during ACS and stroke, underscoring the importance of early lipid assessment and management. Timely intervention with lipid-lowering therapies may help reduce the risk of recurrent cardiovascular events. Further research is needed to explore the underlying mechanisms driving these lipid alterations and to develop targeted strategies for optimizing patient outcomes.