Effect Of Low-Dose Propofol On Post-Operative Nausea and Vomiting In Laparoscopic Surgery Under General Anesthesia
Keywords:
Propofol infusion; post-operative nausea; vomiting; laparoscopic surgery; anesthesia; antiemetic; PONVAbstract
Introduction: Post-operative nausea and vomiting (PONV) are common complications following laparoscopic surgery under general anesthesia, particularly due to the use of volatile anaesthetics and the creation of pneumoperitoneum. Propofol, an intravenous aesthetic, has shown promise in reducing PONV due to its antiemetic properties. This study aims to evaluate the effectiveness of low-dose propofol infusion in minimizing PONV in laparoscopic surgery.
Objective: To assess the impact of continuous low-dose propofol infusion (1 mg/kg/hr) on the incidence and severity of PONV in patients undergoing laparoscopic surgery under general anesthesia, and to compare it with standard anesthesia practices.
Methods: This prospective, randomized, double-blind study was conducted on 80 patients scheduled for elective laparoscopic surgeries. Patients were randomly assigned to receive either low-dose propofol infusion (n=40) or normal saline (n=40) after anesthesia induction. Data on the incidence of PONV, the need for rescue antiemetics, and post-operative recovery parameters were collected. Statistical analysis was performed to compare the outcomes between the two groups.
Results: The propofol group exhibited a significantly lower incidence of PONV (12.5%) compared to the normal saline group (40%) (p=0.007). The need for rescue antiemetics was also reduced in the propofol group (15% vs. 45%). Additionally, propofol infusion resulted in lower scores on the Bellville scale at 1-, 3-, 6-, and 12-hours post-surgery, indicating reduced nausea and vomiting.
Conclusion: Continuous low-dose propofol infusion significantly reduces the incidence and severity of PONV in patients undergoing laparoscopic surgery. It also decreases the need for rescue antiemetics, improving patient comfort and recovery outcomes. This approach presents a viable strategy for PONV management in high-risk patients undergoing laparoscopic procedures.
