Correlation of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio with grades of Urine Albumin Creatinine Ratio In Type-2 Diabetes Mellitus

Abstract

 Diabetes mellitus causes both macrovascular and microvascular complications like nephropathy, retinopathy, and neuropathy. Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) are easily available markers. In our study, we analyzed the correlation of NLR and PLR with grades of urine Albumin Creatinine Ratio (UACR) in Type-2 Diabetes Mellitus.

 Methods – The study was conducted on 200 diabetic patients. They were divided into three groups - group A1(0-30 mg/gm), A2(30-300 mg/gm), and A3(≥300mg/gm) according to UACR values. The correlation between NLR and PLR values was analyzed in each of these groups. 

Result – Among 200(195 males and 95 females) study subjects, 31.5% male patients and 31.6% female patients belonged to the 41-50 age group, and the mean age was (50.73±11.8 years). The values of fasting plasma glucose were (165.63±63.11 mg/dl), 2-hour postprandial plasma glucose was (259.42±94.75 mg/dl), and glycated hemoglobin (HbA1c) was (9.84±7.46%) respectively. The mean NLR was (4.18±3.71), and PLR was (132.03±110.03). We found a significant correlation between NLR and PLR values with UACR grades( P<0.05). Cutoff value, Sensitivity, Specificity, and Accuracy for NLR were 3.1, 69.1%, 68.4%, and 79.3%, respectively, and for PLR were 123.1, 43.6%, 94.7%, and 69.9% respectively. Age and gender did not have a significant effect on NLR and PLR in relation to UACR (p>0.05). 

Conclusion- We found a positive correlation between NLR and PLR with UACR grades. So NLR and PLR can be useful to assess the stage of Diabetic Nephropathy as regards UACR values, specially in resource-limited settings.