A Review Article Role of serum Netrin as Potential Biomarker in Diagnosis and Treatment of Type-2 Diabetes Mellitus

Abstract

Diabetes stands as a complex metabolic syndrome with global prevalence, posing a substantial long-term health challenge. It's intricately linked to a cascade of microvascular and macrovascular complications, significantly impacting quality of life, longevity, and economic well-being on a global scale. Addressing the progression of diabetes and its associated complications has become a paramount objective for scientific endeavors worldwide. Despite the array of diagnostic tools available, there remains a dearth of reliable markers to predict and monitor the onset and advancement of diabetic complications. Recently, attention has turned toward Netrin as a promising biomarker not only for diabetes but also for a spectrum of its enduring complications. This review aims to delve into the multifaceted role of Netrin as a potential biomarker and therapeutic target in diabetes and its diverse microvascular and macrovascular complications. Furthermore, it seeks to unravel the underlying mechanisms through which Netrin exerts its pharmacological effects, shedding light on the intricate pathways involved in the development and progression of diabetes and its complications with a focus on this protein.Understanding the role of Netrin could pave the way for early interventions at the subclinical stage, enabling proactive measures and the assessment of responses to preventative or therapeutic interventions. Moreover, it holds the potential to drive the exploration of novel therapeutic avenues for diabetes and its complications by modulating endogenous Netrin levels and serving as surrogate endpoints for intervention studies.